Instead, Luca runs away with Alberto to the town of Portorosso. Their plans nearly come to a halt, however, when Luca’s frightful parents threaten to make him live his oddball Uncle Ugo ( Sacha Baron Cohen, essentially using his Borat voice in a fish) in the trenches. They dream of buying a vespa and traveling the globe together. Once on dry land, Alberto and Luca form a quick bond. But for Luca, such power dangles greater temptation over him. Their ability isn’t controllable, however, as touching water reverts their skin back to their real scaly exterior. Rather than an evil witch granting him a human appearance, a la “The Little Mermaid,” the sea monsters here can naturally, magically turn mortal. If you’re wondering how these creatures with fins, scales, and tails can could live on among humans without being discovered, writers Jesse Andrews (“ Me and Earl and the Dying Girl”) and Mike Jones (“ Soul”) have a tidy solution for that. As does Alberto, an older, confident amphibian boy who now lives alone in a crumbling castle tower by the beach, and claims his father is temporarily traveling. These items draw Luca closer to the surface. Nevertheless, dry world affectations fall to the ocean floor: an alarm clock, a playing card, and a wrench. Looming against his desires are his mother ( Maya Rudolph) and father’s ( Jim Gaffigan) fear from living by a human, sea-monster-hunting oceanfront village.
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Here are the top hip-record labels in the music industry. With that said, there is still something special about heavyweight record labels. Although this sort of depletes the strength of renowned hip-hop labels as the rosters naturally thin out due to musicians veering off into ever-shrinking subsidiaries - it has become understandable why the music artists are pursuing record labels of their own.įor musical and financial reasons, music artists of commercial caliber look to take control over their brand appeal. Things often get muddled as every hip-hop artist had this need to have their own record label, staffed with their own artists, as they try to expand their positions within the market. Diddy's Bad Boy Records and Eazy-E's Ruthless Records. Dre's Aftermath Entertainment, Interscope gave rise to Suge Knight's Death Row Records, while Sony gave birth to P. But here's what we are doing to reduce our environmental impact.Nowadays, it has become hard to keep track of the successful record labels in hip-hop, given the family-tree-like hierarchical structures of labels these days.įor instance, the Young Money Entertainment record label was founded by Lil' Wayne and it is an imprint of Birdman's Cash Money Records, which happens to be distributed by Republic Records, which is a division of Universal Music Group, a major record label.ĭuring hip-hop's golden year, record label structures used to be simpler - Universal gave the industry Def Jam, Dr. There's no escaping the fact that vinyl records, CDs and tapes are all made from oil, and that getting your orders from us to you consumes yet more oil. If you're not happy with any of your items return them sealed and unused within 45 days for a replacement or refund. You never have to wait for an item you want immediately. because you don't want to wait for any preorders) then we are always happy to do that, subject to any shipping costs. Doing things this way is easier to manage, and helps to reduce shipping costs. If you have an order with us already then we automatically add any new items into that order. Sorry!Ĭombining, splitting and adding to orders Once we have dispatched your order it's impossible to give a firm prediction of transit time for overseas orders as it's so variable. But if your order contains preorders or other items that are not in stock then we can only pack and dispatch once we have your items. If your order contains only in-stock items then we can usually pack and dispatch very quickly (Monday to Friday at least). the transit time of our shipping suppliers.the time it takes for us to pack and dispatch your order.the stock status of the items in your order.The time it takes for your order to arrive is determined by three things: You will need to proceed to checkout for a final cost including shipping options. To estimate shipping costs simply add the items you want to your cart and an initial calculation based on weight and destination will be shown. Overseas shipping is calculated according to the weight of your order, the destination country, and the shipping options you choose (e.g. Sign up here and start collecting points today. You can then convert your points into store vouchers.Īll you need is a (free) Norman Records account. You earn NormanPoints every time you order. Read more about our Guaranteed Packaging » We use extra-strong mailers for all LPs and will even remove records from their sleeves if you ask us to.īut if anything does go wrong? Send us a photo and we will replace, refund or compensate - no questions asked. We take a lot of care when packing your vinyl. Shop around and if you spot something cheaper elsewhere let us know. When it comes to vinyl we're confident we can match almost any price. It's not an idle boast, as our 24915 independently-verified Feefo reviews testify.Įmail is best if you need any support: Our working hours are Monday to Friday, 9am until 4:30pm (UK time). We pride ourselves on offering the best service. Essential shopping info » Customer service & support Read more about our shipping costs, our excellent customer service, our unique Vinyl Price Match, our no-fuss returns policy, the guaranteed packaging we offer, etc. Treatment with carfilzomib-lenalidomide-dexamethasone with lenalidomide extension in patients with smoldering or newly diagnosed multiple myeloma. Korde N, Roschewski M, Zingone A, Kwok M, Manasanch EE, Bhutani M, Tageja N, Kazandjian D, Mailankody S, Wu P, Morrison C, Costello R, Zhang Y, Burton D, Mulquin M, Zuchlinski D, Lamping L, Carpenter A, Wall Y, Carter G, Cunningham SC, Gounden V, Sissung TM, Peer C, Maric I, Calvo KR, Braylan R, Yuan C, Stetler-Stevenson M, Arthur DC, Kong KA, Weng L, Faham M, Lindenberg L, Kurdziel K, Choyke P, Steinberg SM, Figg W, Landgren O. Modern multiple myeloma therapy: deep, sustained treatment response and good clinical outcomes. Better therapy requires better response evaluation: paving the way for minimal residual disease testing for every myeloma patient. Adapters share their personal connections about how cancer has impacted their lives and discuss the critical role of minimal residual disease (MRD) testing t. A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma. Jakubowiak AJ, Dytfeld D, Griffith KA, Lebovic D, Vesole DH, Jagannath S, al-Zoubi A, Anderson T, Nordgren B, Detweiler-Short K, Stockerl-Goldstein K, Ahmed A, Jobkar T, Durecki DE, McDonnell K, Mietzel M, Couriel D, Kaminski M, Vij R. Demonstration of MM MRD biology should help us to deal with the curative difficulties.īiology Gene expression Minimal residual disease Multiple myeloma Omics. Minimal Residual Disease by Flow Cytometry: Latest Insights on Validation Tuesday, JShare Despite the development of cellular and antibody-based therapeutics that eliminate malignant cells, patients who have achieved complete remission or response may experience relapse. To summarize, the MRD stage of disease represents a critical step in MM pathogenesis and progression. Lastly, on the aspect of omics, we performed data-based analysis to address the biological features underlying the course of diagnostic-to-MRD MM. The dynamics from the diagnostic MM to MRD correlate with the disease prognosis. Clonal evaluation may occur at the MRD stage in MM. Diagnostic high-risk MM and low-risk MM exhibited a diversity of MRD features. Rather, MM MRD exhibits unique signatures of cytogenetic aberration and gene expression profiles, unlike those of MM cells before therapy. Rather, MM MRD exhibits unique signatures of cytogenetic aberration and gene expression profiles, unlike those of MM cells before therapy. MRD studies strongly indicate that MRD is not a uniform declination of whole MM tumor population. Minimal residual disease (MRD) detection by ow cytometry. Most important, we reviewed our current understanding of MM MRD biology. We also reviewed different methods that were used for MM MRD assessment. In this review article, we outlined the major clinical trials that have determined the prognostic value of MRD in MM. MRD indicates the depth of post-therapeutic remission. The term minimal residual disease conventionally refers to disease in the bone marrow space. Clinical evidence shows that the status of minimal residual disease (MRD) after treatment is an independent prognostic factor of MM. Multiple myeloma (MM) is a treatable plasma cell cancer with no cure. While Loki is Odin's betrayer and adversary, and all jotuns are evil and must be defeated. It appears on ancient archeological finds on scenes that appear to be human sacrifices by. The Valknut symbol itself, however, dates back to ancient times and relates to the cult of the dead. In modern Asatru we tend to call it the insert spear here symbol. The name ‘Valknut’ is a modern word, meaning ‘slain warrior knot’, and was created recently in the Norwegian language. Humans exist to die honorably in battle so that they can follow Odin. Generic - Pulsera vikinga de cuero con cuentas de runas Valknut de acero inoxidable para hombres, brazalete trenzado con amuleto del símbolo de Odín nórdico, joyería pagana estilo punk gótico Asatru para mujeres Accesorios de moda (Plata 21. The Valknut (pronounced: val-knoot) is a symbol in Nordic mythology depicting three interlocked triangles. Odin is regarded as a warrior king, and it is the duty of all others to follow and fight alongside him. Odin is the supreme god, king, and all-powerful being. Mjölnir, the hammer of Thor, is one of the major symbols of Ásatrú. Odinism is a warrior religion, it shares many similarities with Christianity. Seasonal life cycles, fertility, ancestors, friends, and natural powers are all important. However, we don’t know the true origins of the religion. Life revolves around the gods and spirits asir, vanir, jotuns, and local spirits, and we share our world with all of them. In Asatru, a new-age religion, Valknut is a prominent symbol. However, these two paths are distinctly different.Īsatru is a polytheistic belief system in which all gods and other deities are considered equally important to the world's functioning. Some adherents will use "Ásatrú" as synonymous with "Odinism", others will reject an equivalence between the two terms, while others will reject an equivalence between the two terms, while others will use it synonymously, interchangeably, and try to debunk those who believe the two are completely separate. Game Insight developed the first hidden object game for Facebook, Mystery Manor. Game Insight is known for its free-to-play games for iOS, Android, Windows Store, such as Paradise Island, Airport City, The Tribez. The company was founded in 2009 in Moscow and was being run by Antanas Miseikis as the Deputy CEO, with former founder Alisa Chumachenko stepping down in 2014. Game Insight is a Lithuanian video game developer and publisher of free-to-play mobile games and social-network games, headquartered in Vilnius, Lithuania. With this improved BlueStacks version you can do more and get more.Paradise Island, Mystery Manor, Airport City, The Tribez, Guns of Boom. 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Coetzee also lost a second WBA title shot when he challenged Mike Weaver in 1980 and was stopped in the 13th round.Ĭoetzee had stopped former undisputed heavyweight champion Leon Spinks in the first round in Monaco in 1979 in his first fight outside South Africa, making the world aware of his ability. He saw it as a gift from me and I was grateful for that," Coetzee said.Ĭoetzee finally won the heavyweight title on his third attempt after losing to John Tate in 1979 in a fight for the WBA belt made vacant by Muhammad Ali's retirement. Mandela didn't even flinch when he learned where the medal came from, Coetzee said, and graciously accepted the gift. I was surprised to hear that he had listened to radio commentaries of a few of my fights while he was in prison."Īt a later meeting with Mandela, Coetzee wanted to give the Nobel Peace Prize winner a gift in return and chose a medal that he had previously been awarded by the apartheid government. "It was a surreal moment and he awarded me a medal. Mandela was leading the way," Coetzee said. "It was overwhelming because the country was preparing for democracy and Mr. Mandela, who would become South Africa's first democratically-elected president in 1994, had just been released from prison after 27 years for fighting against apartheid. The government said millions of Black South Africans rooted for Coetzee during his career, "thereby confounding the false logic of apartheid."Ĭoetzee said one of his most treasured moments came when Mandela, a big boxing fan, asked to meet him in the early 1990s. They did in South Africa and Coetzee was awarded the The Order of Ikhamanga in Bronze in 2003 by South Africa's democratically-elected post-apartheid government for his boxing success and for his contribution to "nation-building through sport." "What makes me happy is for Black, brown and white people to accept me as their fighter." "I feel I am fighting for everybody, Black and white," Coetzee said. He knocked out American rival Michael Dokes in the 10th round in Richfield, Ohio, in 1983 to win the WBA belt, a big upset that was celebrated throughout South Africa despite it being fragmented at the time by the apartheid laws of racial segregation.Ĭoetzee's victory also made him the first white boxer to win a world heavyweight title in more than 20 years but he made clear after the fight against Dokes how much he disliked being labeled "the great white hope." He was 67.Ĭoetzee died on Thursday in Cape Town just over a week after being diagnosed with lung cancer, his former manager, Thinus Strydom, said Friday.Ĭoetzee, who was white, was the first African boxer to win a world heavyweight title. Send us feedback.Gerrie Coetzee, former WBA heavyweight champion, dies at 67ĬAPE TOWN, South Africa - Gerrie Coetzee, a former South African boxer and WBA heavyweight champion who defied some of his country's racist laws during the height of apartheid in the 1970s and 1980s and won popularity with Nelson Mandela and both Black and white fans, has died. These example sentences are selected automatically from various online news sources to reflect current usage of the word 'black box.' 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Adjective Binance itself has been a black box, offering little information about its financials or even where it is based, the Journal has previously reported. In this intense, fast-paced multiplayer combat, there could be a maximum of 12 players that can play the game. The game has multiple game modes to enjoy, such as deathmatch and zone control. The Gameplay of the Shadowgun: Deadzone is unique in itself. Thus, it would not be incorrect to mention that it is hard to get bored of this game. It has unique gameplay, stunning visuals, extraordinary weapons, various locations, and many more to name. Apart from that, the game has all the essential features that one action game must-have. The Shadowgun is the perfect game if you are looking for some intense multiplayer. It will be a shock if you have not heard about the game. Edgar Simon, a bioengineer formerly employed by Toltech who has stolen a series of genetic samples.A game that has gathered a ton of praises in recent times. 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